A New Histone Deacetylase Inhibitor, MHY219, Inhibits the Migration of Human Prostate Cancer Cells via HDAC1

  title={A New Histone Deacetylase Inhibitor, MHY219, Inhibits the Migration of Human Prostate Cancer Cells via HDAC1},
  author={Umasankar De and Soma Kundu and Nabanita Patra and Mee Young Ahn and Ji Hae Ahn and Ji Yeon Son and Jung Hyun Yoon and Hyung Ryoung Moon and Byung Mu Lee and Hyung Sik Kim},
  journal={Biomolecules \& Therapeutics},
  pages={434 - 441}
Histone deacetylase (HDAC) inhibitors are considered novel agents for cancer chemotherapy. We previously investigated MHY219, a new HDAC inhibitor, and its potent anticancer activity in human prostate cancer cells. In the present study, we evaluated MHY219 molecular mechanisms involved in the regulation of prostate cancer cell migration. Similar to suberanilohydroxamic acid (SAHA), MHY219 inhibited HDAC1 enzyme activity in a dose-dependent manner. MHY219 cytotoxicity was higher in LNCaP (IC50=0… 

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