A New G-Quadruplex with Hairpin Loop Immediately Upstream of the Human BCL2 P1 Promoter Modulates Transcription.

@article{Onel2016ANG,
  title={A New G-Quadruplex with Hairpin Loop Immediately Upstream of the Human BCL2 P1 Promoter Modulates Transcription.},
  author={Buket Onel and Megan Carver and Guanhui Wu and Daria Timonina and Salil Kalarn and Marti M Larriva and Danzhou Yang},
  journal={Journal of the American Chemical Society},
  year={2016},
  volume={138 8},
  pages={2563-70}
}
The abnormal overexpression of the BCL2 gene is associated with many human tumors. We found a new 28-mer G-quadruplex-forming sequence, P1G4, immediately upstream of the human BCL2 gene P1 promoter. The P1G4 is shown to be a transcription repressor using a promoter-driven luciferase assay; its inhibitory effect can be markedly enhanced by the G-quadruplex-interactive compound TMPyP4. G-quadruplex can readily form in the P1G4 sequence under physiological salt condition as shown by DMS… CONTINUE READING
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and A

  • G. S. Choudhary, S. Al-harbi, +4 authors E. D. Hs
  • Almasan, Cell Death and Disease,
  • 2015

Sci

  • B. Onel, C. Lin, D. Yang
  • China Chem.,
  • 2014

and L

  • S. Kendrick, H. J. Kang, +5 authors S. M. Hech
  • H. Hurley, J Am Chem Soc,
  • 2014

and M

  • P. Juin, O. Geneste, F. Gautier, S. Depi
  • Campone, Nat Rev Cancer,
  • 2013

Chem

  • Y. Chen, P. Agrawal, +4 authors J. Am
  • Soc.,
  • 2012

L

  • X. D. Wang, T. M. Ou, +7 authors D. Li
  • Q. Gu and Z. S. Huang, J Med Chem,
  • 2010

Nucl

  • Z. Zhang, J. Dai, E. Veliath, R. A. Jones, D. Z. Yang
  • Acids Res.,
  • 2010

and I

  • M. I. Onyshchenko, T. I. Gaynutdinov, E. A. Englund, D. H. Appella, R. D. Neuman
  • G. Panyutin, Nucleic Acids Res.,
  • 2009

and D

  • J. Dai, D. Chen, R. A. Jones, L. H. Hurle
  • Yang, Nucleic Acids Res,
  • 2006

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