A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

  title={A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior},
  author={Eyal Vardy and J Elliott Robinson and Chia Yen Li and Reid H. J. Olsen and Jeffrey F Diberto and Patrick M. Gigu{\`e}re and Flori M. Sassano and Xi-Ping Huang and Hu Zhu and Daniel Urb{\'a}n and Kate Lynn White and Joseph E. Rittiner and Nicole A. Crowley and Kristen E. Pleil and Christopher M. Mazzone and Philip D Mosier and Juan Song and Thomas L Kash and Carl J. Malanga and Michael J. Krashes and Bryan L. Roth},
DREADDs are chemogenetic tools widely used to remotely control cellular signaling, neuronal activity, and behavior. Here we used a structure-based approach to develop a new Gi-coupled DREADD using the kappa-opioid receptor as a template (KORD) that is activated by the pharmacologically inert ligand salvinorin B (SALB). Activation of virally expressed KORD in several neuronal contexts robustly attenuated neuronal activity and modified behaviors. Additionally, co-expression of the KORD and the Gq… CONTINUE READING
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