A New Cyclic Peptide and a New Steroid from the Fungus Penicillium sp. GD6 Isolated from the Mangrove Bruguiera gymnorrhiza

@article{Zhou2014ANC,
  title={A New Cyclic Peptide and a New Steroid from the Fungus Penicillium sp. GD6 Isolated from the Mangrove Bruguiera gymnorrhiza},
  author={Zhen-Fang Zhou and Xiao-hong Yang and Hai-li Liu and Yucheng Gu and Bo-ping Ye and Yue‐Wei Guo},
  journal={Helvetica Chimica Acta},
  year={2014},
  volume={97},
  pages={1564-1570}
}
A rare new cyclic tetrapeptide, 5,5′-epoxy-MKN-349A (1), featured by a MKN-349A (5) skeleton and containing an uncommon ether bridge between C(5) and C(5′), and a new steroid, named 11-O-acetyl-NGA0187 (2), together with two known steroids, 3 and 4, were isolated from an endophytic fungus Penicillium sp. GD6 associated with the Chinese mangrove Bruguiera gymnorrhiza. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analyses and by comparison with the… 
7 Citations
Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities.
TLDR
This review summarizes the discovery relating to the source and characteristics of metabolic products isolated from mangrove-associated fungi over the past thirty years, focusing on bioactivity and the unique chemical diversity of these natural products.
Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides
TLDR
This review highlights the occurrence, structures and biological activities of fungal cyclic peptides (excluding cyclodipeptides, and peptides containing ester bonds in the core ring) reported until August 2017.
Scalable Synthesis of Cyclocitrinol.
TLDR
A 10-step synthesis of the C25 steroid natural product cyclocitrinol from inexpensive, commercially available pregnenolone is reported, providing experimental support for the biosynthetic origin of cycloc itrinol.

References

SHOWING 1-10 OF 21 REFERENCES
Penibruguieramine A, a novel pyrrolizidine alkaloid from the endophytic fungus Penicillium sp. GD6 associated with Chinese mangrove Bruguiera gymnorrhiza.
TLDR
The absolute configuration of penibruguieramine A was established by TDDFT ECD calculations of the vacuum and solution conformers, exploiting the transitions of the lactam chromophore.
Two new dihydroisocoumarins from the endophytic fungus Aspergillus sp. collected from the south china sea
Two new dihydroisocoumarin derivatives, aspergillumarins A and B (1 and 2), were isolated from the culture broth of a marine-derived fungus Aspergillus sp., which was isolated from the fresh leaf of
The metabolites of a mangrove endophytic fungus, Penicillium thomi
The chemical constituents research of the fermentation of Penicillium thomi separated from the root of Bruguiera gymnorrhiza led to the isolation of a new compound,
Meroterpenoid and diphenyl ether derivatives from Penicillium sp. MA-37, a fungus isolated from marine mangrove rhizospheric soil.
Penicillium sp. MA-37, which was obtained from the rhizospheric soil of the mangrove plant Bruguiera gymnorrhiza, exhibited different chemical profiles in static and shaken fermentation modes. Three
A new cyclic peptide from a marine-derived bacterium of the genus Nocardiopsis.
TLDR
A new cyclic tetrapeptide was isolated from the culture broth of an actinomycete of the genus Nocardiopsis collected from the Pacific deep-sea sediment on the basis of combined chemical and spectral methods.
Streptomycindole, an Indole Alkaloid from a Marine Streptomyces sp. DA22 Associated with South China Sea Sponge Craniella australiensis
A new indole alkaloid, streptomycindole (1), and a known related compound, N-phenylacetyl-L-tryptophan (2), have been isolated from Streptomyces sp. DA22, associated with South China Sea sponge
Unprecedented occurrence of isoaspartic acid in a plant cyclopeptide.
TLDR
Three structurally related cycloheptapeptides, cyclocitropsides A-C, have been isolated from a MeOH extract of the root bark of Citropsis articulata, a medicinal plant in Uganda and the first report of an isoAsp residue in a plant cyclic peptide is reported.
Unusual C25 steroid isomers with bicyclo[4.4.1]A/B rings from a volcano ash-derived fungus Penicillium citrinum.
TLDR
The results showed that compounds 1, 2, 10, 11, and 14 could induce the production of cAMP in GPR12-transfected CHO cells, and the biological activities of all 16 steroids were tested using the cAMP assay.
...
...