A New Concept for Melatonin Deficit: On Pineal Calcification and Melatonin Excretion

@article{Kunz1999ANC,
  title={A New Concept for Melatonin Deficit: On Pineal Calcification and Melatonin Excretion},
  author={D. Kunz and Stephan Schmitz and R. Mahlberg and Anabelle Mohr and Christiane St{\"o}ter and K. Wolf and W. Herrmann},
  journal={Neuropsychopharmacology},
  year={1999},
  volume={21},
  pages={765-772}
}
Even though exogenous melatonin has proven to influence sleep and circadian parameters, low endogenous melatonin is not related to sleep disturbances, nor does it predict response to melatonin replacement therapy. In this manuscript, we present a new concept towards a definition of a melatonin deficit. The purpose of the study was to introduce a marker for an intra-individual decrease in melatonin production. Therefore, we developed a method to quantify the degree of pineal calcification (DOC… Expand
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References

SHOWING 1-10 OF 66 REFERENCES
Prediction of nocturnal plasma melatonin from morning urinary measures
TLDR
The results support the inclusion of morning urine samples to assess the contribution of the hormone melatonin in occupational or residential studies involving healthy, young men, and show good sensitivity and specificity in identifying individual differences in nocturnal plasma melatonin levels. Expand
On pineal calcification and its relation to subjective sleep perception: a hypothesis-driven pilot study
TLDR
This study provides initial confirmation of the hypothesis that the increasing degree of pineal calcification might indicate a decrease of melatonin production, which consecutively might lead to a disturbed circadian rhythmicity in the sleep-wake cycle, with the principal symptom being daytime tiredness. Expand
Lack of pineal growth during childhood.
TLDR
The data presented indicate a lack of a discernible pineal growth after age 1 yr, which contrasts with pituitary development in the same individuals, in agreement with a hypothesis suggesting a growth arrest of the pineal after infancy. Expand
Low and high melatonin excretors among healthy individuals
TLDR
The distinction between low and high nocturnal excretion and by inference secretion of melatonin most likely reflects genetically determined variable levels of the noradrenergic secretory drive and/or variable N‐acetyltransferase/hy‐droxyindole‐O‐methyltransferase enzymatic activity during the night. Expand
The Decrease of Pineal Melatonin Production with Age
TLDR
The hypothesis of “loss of circadian rhythmicity in aging” is supported by numerous animal studies and is hypothesized that the gradual and progressive deterioration of functional potential is the result of the loss of coordination among the many interdependent oscillating systems. Expand
Decreased melatonin biosynthesis, calcium flux, pineal gland calcification and aging: a hypothetical framework.
TLDR
A comprehensive framework for the interaction of aging pineal cell mechanisms, calcium flux and melatonin biosynthesis is presented and supports the notion of a pineal bio-organic timing mechanism. Expand
Improvement of sleep quality in elderly people by controlled-release melatonin
TLDR
Controlled-release melatonin replacement therapy effectively improves sleep quality in this population of elderly people and may have an important role in the high frequency of insomnia among elderly people. Expand
FACTORS INFLUENCING URINARY 6‐SULPHATOXYMELATONIN, A MAJOR MELATONIN METABOLITE, IN NORMAL HUMAN SUBJECTS
TLDR
The usefulness of aMT6s as an index of melatonin secretion in normal volunteers is confirmed, by a direct radioimmunoassay, in urine from 130 normal volunteers aged 2–80 years. Expand
Alterations in nocturnal serum melatonin levels in humans with growth and aging.
TLDR
The negative correlation between serum MLT and body weight in childhood and adolescence is evidence that expansion of body size is responsible for the huge MLT decrease during that period, and the moderate decline at older ages must derive from other factors. Expand
Changes in circadian rhythms and sleep quality with aging: Mechanisms and interventions
TLDR
Changes in circadian rhythms are frequently associated with a reduction in nighttime sleep quality, a decrease in daytime alertness, and an attenuation in cognitive performance; reversing such changes could enhance the quality of life for a large and rapidly increasing percentage of the population. Expand
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1
2
3
4
5
...