A Neuronal Isoform of the Aplysia CPEB Has Prion-Like Properties

  title={A Neuronal Isoform of the Aplysia CPEB Has Prion-Like Properties},
  author={Kausik Si and Susan Lindquist and Eric R Kandel},
Prion proteins have the unusual capacity to fold into two functionally distinct conformations, one of which is self-perpetuating. When yeast prion proteins switch state, they produce heritable phenotypes. We report prion-like properties in a neuronal member of the CPEB family (cytoplasmic polyadenylation element binding protein), which regulates mRNA translation. Compared to other CPEB family members, the neuronal protein has an N-terminal extension that shares characteristics of yeast prion… CONTINUE READING
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