A Neurobiological Model of Insomnia.

@article{Buysse2011ANM,
  title={A Neurobiological Model of Insomnia.},
  author={Daniel J Buysse and Anne Laure Germain and Martica H. Hall and Timothy H. Monk and Eric A. Nofzinger},
  journal={Drug discovery today. Disease models},
  year={2011},
  volume={8 4},
  pages={
          129-137
        }
}
Insomnia is a common clinical condition resulting in significant costs and morbidity. Previous models of insomnia focusing on psychological and behavioral processes are useful clinically, but lack neurobiological specificity. We propose an insomnia model based on basic and clinical neuroscience findings, and hypothesize that insomnia results from persistent activity in wake-promoting neural structures during NREM sleep. The simultaneous occurrence of sleeping and waking neural activity helps to… CONTINUE READING

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