A Neural Marker of Obsessive-Compulsive Disorder from Whole-Brain Functional Connectivity

@article{Takagi2017ANM,
  title={A Neural Marker of Obsessive-Compulsive Disorder from Whole-Brain Functional Connectivity},
  author={Yu Takagi and Yuki Sakai and Giuseppe Lisi and Noriaki Yahata and Yoshinari Abe and Seiji Nishida and Takashi Nakamae and Jun Morimoto and Mitsuo Kawato and Jin Narumoto and Saori C. Tanaka},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
Obsessive-compulsive disorder (OCD) is a common psychiatric disorder with a lifetime prevalence of 2–3%. Recently, brain activity in the resting state is gathering attention for exploring altered functional connectivity in psychiatric disorders. Although previous resting-state functional magnetic resonance imaging studies investigated the neurobiological abnormalities of patients with OCD, there are concerns that should be addressed. One concern is the validity of the hypothesis employed. Most… 
Inhibition-Related Cortical Hypoconnectivity as a Candidate Vulnerability Marker for Obsessive-Compulsive Disorder
Diagnostic neuroimaging markers of obsessive-compulsive disorder: Initial evidence from structural and functional MRI studies
Individual-fMRI-approaches reveal cerebellum and visual communities to be functionally connected in obsessive compulsive disorder
TLDR
The study demonstrated the existence of disconnectedness in fronto-striato-limbic community and connectedness between cerebellar and visual areas in OCD patients, which was also related to the clinical symptomatology of OCD.
Investigating the predictive value of different resting-state functional MRI parameters in obsessive-compulsive disorder
TLDR
The application of SVM to rs-fMRI features may provide potential power for OCD classification and the brain regions showing the greatest discriminative power included the prefrontal cortex, anterior cingulate cortex, precentral gyrus, and occipital lobes.
Common Brain Networks Between Major Depressive-Disorder Diagnosis and Symptoms of Depression That Are Validated for Independent Cohorts
TLDR
Using resting- state functional magnetic resonance imaging, resting-state functional connectivity related to depression symptoms that were thought to be directly related to neurobiological abnormalities are determined and validated and contribute to a deeper understanding of the neural circuitry of depressive symptoms in MDD.
Altered network connectivity predicts response to cognitive-behavioral therapy in pediatric obsessive–compulsive disorder
TLDR
This is the first study to show that altered connectivity between large-scale network regions may predict response to CBT in pediatric OCD, highlighting the clinical relevance of these networks as potential circuit-based targets for the development of novel treatments.
Reduction of brooding and more general depressive symptoms after fMRI neurofeedback targeting a melancholic functional-connectivity biomarker
TLDR
FMRI functional connectivity neurofeedback was used to target a neural biomarker that objectively relates to a specific subset (melancholic) of depressive symptoms and that is generalizable across independent cohorts of patients, and found that the more a participant normalized this biomarker, symptoms were reduced.
Defining data-driven subgroups of obsessive–compulsive disorder with different treatment responses based on resting-state functional connectivity
TLDR
The results highlight that not only abnormalities within the DMN but also aberrant rsFC between theDMN and other networks may contribute to the treatment response and support the importance of these neurobiological alterations in OCD patients.
A common neural network among state, trait, and pathological anxiety from whole-brain functional connectivity
TLDR
The findings provide direct evidence that different dimensions of anxiety are not completely independent but have a substantial biological inter-relationship and provide a biologically defined dimension of anxiety, which may promote further investigation of various human characteristics, including psychiatric disorders, from the perspective of anxiety.
...
...

References

SHOWING 1-10 OF 85 REFERENCES
Altered corticostriatal functional connectivity in obsessive-compulsive disorder.
TLDR
This study directly supports the hypothesis that OCD is associated with functional alterations of brain corticostriatal networks, as measured from coherent spontaneous fluctuations in the blood oxygenation level-dependent signal.
Default mode network subsystem alterations in obsessive–compulsive disorder
TLDR
Results indicate that people with OCD show abnormalities in a neural system previously associated with self-referential processing in healthy individuals, and suggest the need for examination of dynamic interactions between this default mode network subsystem and other large-scale networks in this disorder.
Neurocognitive endophenotypes of obsessive-compulsive disorder.
TLDR
Structural variation in large-scale brain systems related to motor inhibitory control may mediate genetic risk for OCD, representing the first evidence for a neurocognitive endophenotype of OCD.
Independent component analysis of resting state activity in pediatric obsessive‐compulsive disorder
TLDR
Findings implicate resting state fMRI abnormalities within the cingulate cortex and related control regions in the pathogenesis and phenomenology of OCD early in the course of the disorder and prior to extensive pharmacologic intervention.
...
...