A Network Model for the Correlation between Epistasis and Genomic Complexity

  title={A Network Model for the Correlation between Epistasis and Genomic Complexity},
  author={Rafael Sanju{\'a}n and Miguel R. Nebot},
  journal={PLoS ONE},
  pages={435 - 440}
The study of genetic interactions (epistasis) is central to the understanding of genome organization and evolution. A general correlation between epistasis and genomic complexity has been recently shown, such that in simpler genomes epistasis is antagonistic on average (mutational effects tend to cancel each other out), whereas a transition towards synergistic epistasis occurs in more complex genomes (mutational effects strengthen each other). Here, we use a simple network model to identify… CONTINUE READING

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