A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1

@article{Hertz2013ANT,
  title={A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1},
  author={Nicholas T. Hertz and Amandine Berthet and Martin L Sos and Kurt S. Thorn and Al L. Burlingame and Ken Nakamura and Kevan M. Shokat},
  journal={Cell},
  year={2013},
  volume={154},
  pages={737-747}
}
Mitochondria have long been implicated in the pathogenesis of Parkinson's disease (PD). Mutations in the mitochondrial kinase PINK1 that reduce kinase activity are associated with mitochondrial defects and result in an autosomal-recessive form of early-onset PD. Therapeutic approaches for enhancing the activity of PINK1 have not been considered because no allosteric regulatory sites for PINK1 are known. Here, we show that an alternative strategy, a neo-substrate approach involving the ATP… CONTINUE READING
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