A Naturally Occurring Domestic Cat APOBEC3 Variant Confers Resistance to Feline Immunodeficiency Virus Infection

@inproceedings{Yoshikawa2016ANO,
  title={A Naturally Occurring Domestic Cat APOBEC3 Variant Confers Resistance to Feline Immunodeficiency Virus Infection},
  author={Rokusuke Yoshikawa and Taisuke Izumi and Eri Yamada and Yusuke Nakano and Naoko Misawa and Fengrong Ren and Michael A Carpenter and Terumasa Ikeda and Carsten M{\"u}nk and Reuben S Harris and Takayuki Miyazawa and Yoshio Koyanagi and Kei Sato and Susan R Ross},
  booktitle={Journal of virology},
  year={2016}
}
UNLABELLED Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3; A3) DNA cytosine deaminases can be incorporated into progeny virions and inhibit lentiviral replication. On the other hand, viral infectivity factor (Vif) of lentiviruses antagonizes A3-mediated antiviral activities by degrading A3 proteins. It is known that domestic cat (Felis catus) APOBEC3Z3 (A3Z3), the ortholog of human APOBEC3H, potently suppresses the infectivity of vif-defective feline immunodeficiency… CONTINUE READING
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