A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda guidelines.

@article{RodriguezBigas1997ANC,
  title={A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda guidelines.},
  author={Miguel Rodriguez-Bigas and Clement Richard Boland and Stanley R. Hamilton and Donald E. Henson and Jeremy R. Jass and Pasha M. Khan and H. Merrill Lynch and Manuel Perucho and Thomas C. Smyrk and Leslie H. Sobin and Sudhir Srivastava},
  journal={Journal of the National Cancer Institute},
  year={1997},
  volume={89 23},
  pages={1758-62}
}
Hereditary nonpolyposis colorectal cancer (HNPCC) is a distinct autosomal dominant syndrome accounting for approximately 5%–6% of the total colorectal cancer burden with clinical and pathologic features caused by defective mismatch repair genes(1). Germline mutations in hMSH2, hMLH1, hPMS1, hPMS2, and MSH6/GTBP have been identified in affected individuals(2,3).HNPCC is characterized by early-onset colorectal cancer (median age at diagnosis 45 years); right-sided predominance; excess synchronous… CONTINUE READING
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Clinical applications of genetic studies in hereditary colorectal cancer

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