A Naphthoquinone Derivative, Shikonin, Has Insulin-Like Actions by Inhibiting Both Phosphatase and Tensin Homolog Deleted on Chromosome 10 and Tyrosine Phosphatases

@article{Nigorikawa2006AND,
  title={A Naphthoquinone Derivative, Shikonin, Has Insulin-Like Actions by Inhibiting Both Phosphatase and Tensin Homolog Deleted on Chromosome 10 and Tyrosine Phosphatases},
  author={K. Nigorikawa and K. Yoshikawa and T. Sasaki and E. Iida and M. Tsukamoto and H. Murakami and T. Maehama and K. Hazeki and O. Hazeki},
  journal={Molecular Pharmacology},
  year={2006},
  volume={70},
  pages={1143 - 1149}
}
  • K. Nigorikawa, K. Yoshikawa, +6 authors O. Hazeki
  • Published 2006
  • Biology, Medicine
  • Molecular Pharmacology
  • The 1,4-naphthoquinone derivative, shikonin, has been shown to increase glucose uptake by adipocytes and myocytes with minor effects on protein tyrosine phosphorylation in the cells (Biochem Biophys Res Commun 292:642-651, 2002). The present study was performed to examine the mechanism of this action of shikonin. Shikonin inhibited the phosphatidylinositol 3,4,5-triphosphate (PtdIns-3,4,5-P3) phosphatase activity of recombinant phosphatase and tensin homolog deleted on chromosome 10 (PTEN) with… CONTINUE READING
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