A Naphthoquinone Derivative, Shikonin, Has Insulin-Like Actions by Inhibiting Both Phosphatase and Tensin Homolog Deleted on Chromosome 10 and Tyrosine Phosphatases

@article{Nigorikawa2006AND,
  title={A Naphthoquinone Derivative, Shikonin, Has Insulin-Like Actions by Inhibiting Both Phosphatase and Tensin Homolog Deleted on Chromosome 10 and Tyrosine Phosphatases},
  author={K. Nigorikawa and K. Yoshikawa and T. Sasaki and E. Iida and M. Tsukamoto and H. Murakami and T. Maehama and K. Hazeki and O. Hazeki},
  journal={Molecular Pharmacology},
  year={2006},
  volume={70},
  pages={1143 - 1149}
}
  • K. Nigorikawa, K. Yoshikawa, +6 authors O. Hazeki
  • Published 2006
  • Biology, Medicine
  • Molecular Pharmacology
    • The 1,4-naphthoquinone derivative, shikonin, has been shown to increase glucose uptake by adipocytes and myocytes with minor effects on protein tyrosine phosphorylation in the cells (Biochem Biophys Res Commun 292:642-651, 2002). The present study was performed to examine the mechanism of this action of shikonin. Shikonin inhibited the phosphatidylinositol 3,4,5-triphosphate (PtdIns-3,4,5-P3) phosphatase activity of recombinant phosphatase and tensin homolog deleted on chromosome 10 (PTEN) with… CONTINUE READING
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    Background Citations
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    Pharmacological Targeting of the Mitochondrial Phosphatase PTPMT1
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    Shikonin Inhibites Migration and Invasion of Thyroid Cancer Cells by Downregulating DNMT1
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    Inhibition of PTEN and activation of Akt by menadione.
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    Akt and phosphoinositide regulation and wortmannin-dependent induction of phospho-Akt in 3T3-L1 adipocytes on cold exposure followed by rewarming
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    Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis Induction
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    SUPPRESSES 3-HYDROXY-3-METHYL-GLUTARYL-COA REDUCTASE AND INDUCES LDL RECEPTOR EXPRESSION IN HEPG 2
    • PDF
    Acetylshikonin stimulates glucose uptake in L6 myotubes via a PLC-β3/PKCδ-dependent pathway.
    • 2
    Shikonin time-dependently induced necrosis or apoptosis in gastric cancer cells via generation of reactive oxygen species.
    • 32

    References

    SHOWING 1-10 OF 38 REFERENCES
    Cell Growth Inhibition by a Novel Vitamin K Is Associated with Induction of Protein Tyrosine Phosphorylation*
    • 55
    • PDF
    Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.
    • 69
    Shikonin stimulates glucose uptake in 3T3-L1 adipocytes via an insulin-independent tyrosine kinase pathway.
    • 51
    Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt.
    • 39
    • PDF
    The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate*
    • 2,894
    • PDF
    Impairment of phosphatidylinositol signaling in acetylshikonin-treated neutrophils.
    • 23
    Shikonins, Phytocompounds from Lithospermum erythrorhizon, Inhibit the Transcriptional Activation of Human Tumor Necrosis Factor α Promoter in Vivo*
    • 132
    • PDF
    Enhancement by Adenosine of Insulin-induced Activation of Phosphoinositide 3-Kinase and Protein Kinase B in Rat Adipocytes*
    • 51
    • PDF
    Bisperoxovanadium compounds are potent PTEN inhibitors
    • 204
    • Highly Influential
    Potent reversible inhibitors of the protein tyrosine phosphatase CD45.
    • 65
    • PDF