Corpus ID: 29925867

A Nanosensor System Based On Disuccinimydyl–CYP2E1 for Amperometric Detection of the Anti-Tuberculosis Drug, Pyrazinamide

@article{Ajayi2014ANS,
  title={A Nanosensor System Based On Disuccinimydyl–CYP2E1 for Amperometric Detection of the Anti-Tuberculosis Drug, Pyrazinamide},
  author={Rachel Fanelwa Ajayi and Unathi Sidwaba and Usisipho Feleni and Samantha Fiona Douman and Ezo Nxusani and Lindsay Wilson and Candice Rassie and Oluwakemi Tovide and Priscilla Gloria Lorraine Baker and Sibulelo L. Vilakazi and Robert Tshikhudo and Emmanuel I. Iwuoha},
  journal={World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering},
  year={2014},
  volume={8},
  pages={67-71}
}
  • R. F. Ajayi, Unathi Sidwaba, +9 authors E. Iwuoha
  • Published 3 January 2014
  • Chemistry, Medicine
  • World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering
Pyrazinamide (PZA) is among the first-line pro-drugs in the tuberculosis (TB) combination chemotherapy used to treat Mycobacterium tuberculosis. Numerous reports have suggested that hepatotoxicity due to pyrazinamide in patients is due to inappropriate dosing. It is, therefore necessary to develop sensitive and reliable techniques for determining the PZA metabolic profile of diagnosed patients promptly and at point-of-care. This study reports the determination of PZA based on nanobiosensor… Expand
An Amperometric Cytochrome P450-2D6 Biosensor System for the Detection of the Selective Serotonin Reuptake Inhibitors (SSRIs) Paroxetine and Fluvoxamine
Paroxetine is the second most prescribed selective serotonin reuptake inhibitor (SSRI) antidepressant drug, characterized by extensive inter-individual variation in steady state plasma concentrationsExpand

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