A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways

@article{Morton2014ANC,
  title={A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways},
  author={Stephen W. Morton and Michael J. Lee and Z. John Deng and Erik C. Dreaden and Elise Siouve and Kevin E. Shopsowitz and Nisarg Shah and Michael B. Yaffe and Paula T Hammond},
  journal={Science Signaling},
  year={2014},
  volume={7},
  pages={ra44-ra44}
}
Exposure to the EGFR (epidermal growth factor receptor) inhibitor erlotinib promotes the dynamic rewiring of apoptotic pathways, which sensitizes cells within a specific period to subsequent exposure to the DNA-damaging agent doxorubicin. A critical challenge for translating this therapeutic network rewiring into clinical practice is the design of optimal drug delivery systems. We report the generation of a nanoparticle delivery vehicle that contained more than one therapeutic agent and… CONTINUE READING
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