A NHERF binding site links the betaPDGFR to the cytoskeleton and regulates cell spreading and migration.

@article{James2004ANB,
  title={A NHERF binding site links the betaPDGFR to the cytoskeleton and regulates cell spreading and migration.},
  author={M. F. James and Roberta L. Beauchamp and Nitasha Manchanda and Andrius Kazlauskas and V Ramakrishnan Ramesh},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 14},
  pages={2951-61}
}
The Na(+)/H(+) exchanger regulatory factor, NHERF, is a multifunctional adapter protein involved in a wide range of physiological activities. NHERF associates with merlin and the ezrin/radixin/moesin (MERM) family of membrane-actin cytoskeletal linker proteins through its C-terminus and is capable of interacting via its PDZ1 domain to the betaPDGF receptor (betaPDGFR). Thus, NHERF, potentially links the betaPDGFR to the actin cytoskeleton through its interaction with MERM proteins. In the… CONTINUE READING
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