A NEW EXPLANATION FOR THE REPRODUCTIVE WOES AND MIDLIFE DECLINE OF HENRY VIII*

@article{Whitley2010ANE,
  title={A NEW EXPLANATION FOR THE REPRODUCTIVE WOES AND MIDLIFE DECLINE OF HENRY VIII*},
  author={Catrina Banks Whitley and Kyra Kramer},
  journal={The Historical Journal},
  year={2010},
  volume={53},
  pages={827 - 848}
}
ABSTRACT Henry VIII's first two wives experienced multiple pregnancies culminating in late-term miscarriage, stillbirth, or neonatal mortality. After his fortieth birthday, the king's mental and physical health underwent rapid deterioration. In this article, we argue that both his reproductive troubles and his midlife pathologies can be explained if Henry VIII were positive for the Kell blood group. A Kell negative woman who has multiple pregnancies with a Kell positive male will suffer… 
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Henry VIII, McLeod syndrome and Jacquetta's curse.
TLDR
A critically review of the coexistence of both Kell blood group antigenicity and McLeod syndrome for Henry VIII, examining in detail the pathophysiology of these conditions and assessing the genealogy of Henry VIII and its effect in subsequent generations.
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This work reviews what was learned from the structural studies of Royal Family members including chromo, Tudor, MBT, chromo barrel, and PWWP domains on methyllysine reader domains for which three-dimensional structures are available in the ligand-bound state.
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The king’s personal interest in medicine and the politics of medicine changed over time, but the nature of the changes and their implications are still unclear.
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McLeod syndrome and Jacquetta ’ s curse

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In a 10-year period, 407 of 350,000 pregnancies showed maternal anti-Kell allo-immunization, i.e., an incidence of 1.16 per 1000 pregnancies. About 88% of Kell immunized women gave a history of…
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