A Mutation in the Mouse Ttc26 Gene Leads to Impaired Hedgehog Signaling

  title={A Mutation in the Mouse Ttc26 Gene Leads to Impaired Hedgehog Signaling},
  author={Ruth E. Swiderski and Yoko Nakano and Robert F. Mullins and Seongjin Seo and Botond B{\'a}nfi and Susan K. Dutcher},
  booktitle={PLoS genetics},
The phenotype of the spontaneous mutant mouse hop-sterile (hop) is characterized by a hopping gait, polydactyly, hydrocephalus, and male sterility. Previous analyses of the hop mouse revealed a deficiency of inner dynein arms in motile cilia and a lack of sperm flagella, potentially accounting for the hydrocephalus and male sterility. The etiology of the other phenotypes and the location of the hop mutation remained unexplored. Here we show that the hop mutation is located in the Ttc26 gene and… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
8 Extracted Citations
89 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-8 of 8 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 89 references

Primary cilia, sonic hedgehog signaling, and spinal cord development

  • LE Mariani, T Caspary
  • 2013
2 Excerpts

Similar Papers

Loading similar papers…