A Mutation in the Mouse Ttc26 Gene Leads to Impaired Hedgehog Signaling

@inproceedings{Swiderski2014AMI,
  title={A Mutation in the Mouse Ttc26 Gene Leads to Impaired Hedgehog Signaling},
  author={Ruth E. Swiderski and Yoko Nakano and Robert F. Mullins and Seongjin Seo and Botond B{\'a}nfi and Susan K. Dutcher},
  booktitle={PLoS genetics},
  year={2014}
}
The phenotype of the spontaneous mutant mouse hop-sterile (hop) is characterized by a hopping gait, polydactyly, hydrocephalus, and male sterility. Previous analyses of the hop mouse revealed a deficiency of inner dynein arms in motile cilia and a lack of sperm flagella, potentially accounting for the hydrocephalus and male sterility. The etiology of the other phenotypes and the location of the hop mutation remained unexplored. Here we show that the hop mutation is located in the Ttc26 gene and… CONTINUE READING
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