A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease.

  title={A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease.},
  author={T. Shen and Ming-Kai Jhan and J. Kao and Min-Ru Ho and Tsung-Ting Tsai and Po-Chun Tseng and Yung-Ting Wang and Chiou-Feng Lin},
  journal={Journal of visualized experiments : JoVE},
Dengue virus (DENV), an arthropod-borne virus transmitted by mosquitoes, may cause the severe disease known as dengue hemorrhagic fever, which is characterized by lethal complications due to plasma leakage, ascites, pleural effusion, respiratory distress, severe bleeding, and organ impairment. A few cases of DENV infection present neurological manifestations; however, studies have not explored DENV-induced neuropathogenesis further. In this study, we present a protocol to use an immunocompetent… Expand
2 Citations
CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain
A CNS immune profile of DENV infection and hypothetical CNS immunity in response toDENV infection is indicated and the time-dependent induction of proinflammatory and NK1.1-associated cytokines in the DENV-infected brains are shown. Expand
Repurposing the Antiemetic Metoclopramide as an Antiviral Against Dengue Virus Infection in Neuronal Cells
Repurposing the D2R-targeting antiemetic MCP is a potential therapeutic strategy against DENV infection and demonstrated the antiviral effect of MCP againstDENV-induced CNS neuropathy and mortality. Expand