A Multiscale Model Evaluates Screening for Neoplasia in Barrett’s Esophagus

@inproceedings{Curtius2015AMM,
  title={A Multiscale Model Evaluates Screening for Neoplasia in Barrett’s Esophagus},
  author={Kit Curtius and William D. Hazelton and Jihyoun Jeon and E. Georg Luebeck},
  booktitle={PLoS Computational Biology},
  year={2015}
}
Barrett's esophagus (BE) patients are routinely screened for high grade dysplasia (HGD) and esophageal adenocarcinoma (EAC) through endoscopic screening, during which multiple esophageal tissue samples are removed for histological analysis. We propose a computational method called the multistage clonal expansion for EAC (MSCE-EAC) screening model that is used for screening BE patients in silico to evaluate the effects of biopsy sampling, diagnostic sensitivity, and treatment on disease burden… CONTINUE READING
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