A Multiscale Entropy-Based Tool for Scoring Severity of Systemic Inflammation*

@article{Vandendriessche2014AME,
  title={A Multiscale Entropy-Based Tool for Scoring Severity of Systemic Inflammation*},
  author={Benjamin Vandendriessche and Harlinde Peperstraete and Elke Rogge and Peter Cauwels and Eric A J Hoste and Oliver Stiedl and Peter Brouckaert and Anje Cauwels},
  journal={Critical Care Medicine},
  year={2014},
  volume={42},
  pages={e560–e569}
}
Objective:Early detection and start of appropriate treatment are highly correlated with survival of sepsis and septic shock, but the currently available predictive tools are not sensitive enough to identify patients at risk. Design:Linear (time and frequency domain) and nonlinear (unifractal and multiscale complexity dynamics) measures of beat-to-beat interval variability were analyzed in two mouse models of inflammatory shock to determine if they are sensitive enough to predict outcome… 
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23 Citations
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Cardiovascular variability as a measure of inflammation*.
TLDR
It is noted that inflammation erodes the structure of the variability, reducing it toward white (1/f ) noise, and further that the erosion in variability structure precedes the changes in vital signs that the authors associate with shock.
Beat-to-beat blood pressure variability: an early predictor of disease and cardiovascular risk.
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The value of linear and nonlinear parameters in reflecting different information about the pathophysiology of changes in beat-to-beat BPV independent of or superior to mean BP is summarized.
Short-Term Model-Based Multiscale Complexity Analysis of Cardiac Control Provides Complementary Information to Single-Scale Approaches
TLDR
It is concluded that short-term model-based linear multiscale complexity approach provides complementary information to single-scale methods in an application devoted to the analysis of cardiac control from 24 hours Holter recordings.
A Framework for Patient State Tracking by Classifying Multiscalar Physiologic Waveform Features
TLDR
A generalizable framework for classifying multiscalar waveform features, designed for patient-state tracking directly at the bedside, that generates meaningful and actionable patient-specific information, and could facilitate the dissemination of a new class of “always-on” diagnostic tools.
Multiscale entropy analysis of heart rate variability in heart failure, hypertensive, and sinoaortic-denervated rats: classical and refined approaches.
TLDR
It is proposed that short time scales (1 to 4), accounting for fast oscillations, are more related to vagal and respiratory control, whereas long time scales [5 to 20], accounting for slow oscillations], are morerelated to sympathetic control.
Periodicity: A Characteristic of Heart Rate Variability Modified by the Type of Mechanical Ventilation After Acute Lung Injury
TLDR
A novel approach to quantify heart rate variability (HRV) and the results of applying this approach to synthetic and original data sets determined that the heart rate (HR) of BVV group had less periodicity and higher variability than the HR of the CMV group.
Assessing multiscale complexity of short heart rate variability series through a model-based linear approach.
TLDR
The approach suggests that the reduction of HP variability complexity observed during graded head-up tilt is due to a regularization of the HP fluctuations in LF band via a possible intervention of sympathetic control and the decrement of HP heterogeneity observed during slow breathing is the result of the regularized variations in both LF and HF bands, thus implying the action of physiological mechanisms working at time scales even different from that of respiration.
Extracellular ATP drives systemic inflammation, tissue damage and mortality
TLDR
It is concluded that removal of systemic extracellular ATP could be a valuable strategy to dampen systemic inflammatory damage and toxicity in SIRS.
Reversible heart rhythm complexity impairment in patients with primary aldosteronism
TLDR
It is suggested that heart rhythm complexity is impaired in APA patients and this is at least partially reversed by adrenalectomy and the conventional HRV parameters did not change.
Data Collection and Analysis in the ICU
TLDR
This chapter will review various types of data in the ICU and methods of analysis including complex systems analysis and “patient state” tracking in theICU.
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