A Multiplatform Approach for the Discovery of Novel Drug-Induced Kidney Injury Biomarkers.

Abstract

Drug-induced kidney injury (DIKI) is a common toxicity observed in pharmaceutical development. We demonstrated the use of label-free liquid chromatography-mass spectrometry (LC-MS) and multiplex liquid chromatography-single reaction monitoring (LC-SRM) as practical extensions of standard immunoassay based safety biomarker assessments for identification of… (More)
DOI: 10.1021/acs.chemrestox.7b00159

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Cite this paper

@article{Chen2017AMA, title={A Multiplatform Approach for the Discovery of Novel Drug-Induced Kidney Injury Biomarkers.}, author={Liuxi Chen and James Smith and Jaromir Mikl and Ryan M. Fryer and Frank Pack and Brad Williams and Jonathan R A Phillips and Vladimir V Papov}, journal={Chemical research in toxicology}, year={2017}, volume={30 10}, pages={1823-1834} }