A Multiobjective Evolutionary Method for the Design of Peptidic Mimotopes

@article{Hohm2006AME,
  title={A Multiobjective Evolutionary Method for the Design of Peptidic Mimotopes},
  author={Tim Hohm and Philipp Limbourg and Daniel Hoffmann},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  year={2006},
  volume={13 1},
  pages={113-25}
}
Peptides that mimic protein epitopes are interesting drug candidates. However, the design of effective peptidic drugs is difficult for several reasons, such as the fast degradation of peptides, their high flexibility, and thus high entropy loss on binding to the target. We therefore propose an in silico method for the automated design of peptides that are optimal with respect to several objectives. We present a Pareto-based multiobjective evolutionary algorithm for in silico peptide design… CONTINUE READING