A Multi-perspective Review of Dengue Research.

  title={A Multi-perspective Review of Dengue Research.},
  author={Masilamani Elizabeth Sobhia and Ketan Ghosh and Ajeet Singh and Komal Sul and Monica Singh and Ravi Kumar and Sandeep and Satti Merugu and Sunilchand Donempudi},
  journal={Current drug targets},
Dengue fever is a disease which is caused by a family of viruses Flaviviridae which are transmitted by female Aedes mosquitoes. Today, this is an endemic in more than 100 nations in the World Health Organization's African, Americas, Eastern Mediterranean, South-East Asia and Western Pacific locales. The treatment of typical dengue is focused on relieving the symptoms and signs. Carica papaya is a very common plant whose leaf extract is used in the treatment of this disease. Despite extensive… 
1 Citations

Bioinformatic Analysis of Envelope Protein Domains of Zika Virus and Dengue Virus

In this study, in-depth analyses of the envelope (E) protein that perform essential functions for host infection of Zika virus and dengue virus based on bioinformatics databases found EDIII showing low homology was identified.



Potential anti-dengue medicinal plants: a review

Current studies show that natural products represent a rich potential source of new anti-dengue compounds, and further ethnobotanical surveys and laboratory investigations are needed to established the potential of identified species in contributing to dengue control.

Dengue virus RNA polymerase NS5: a potential therapeutic target?

The largest and most highly conserved of the dengue proteins, NS5, is examined, including its functions, interactions, subcellular localisation and regulation, and looks at ways in which some of these may be exploited in the quest for effective drugs.

Current perspectives on the spread of dengue in India

More active community-based epidemiological studies with intensive vector control and initiatives for dengue vaccine development should be geared up to control the spread of d Dengue in India.

Review of Current Dengue Treatment and Therapeutics in Development

Several classes of agents are in under investigation as potential anti-dengue drugs, including direct antivirals, host modula - tors, and RNAi therapeutics.

Molecular Docking studies on phytocompounds from the methanol leaf extract of Carica papaya against Envelope protein of dengue virus (type-2)

Investigation of the anti-viral activity of compounds present in the leaves of Carica papaya against envelope protein of dengue 2 virus found that six compounds showed high inhibitory activity against the E protein, concluding that this selected compounds could serve as antiviral drugs for d Dengue infections.

Dengue and Dengue Hemorrhagic Fever

  • D. Gubler
  • Medicine
    Clinical Microbiology Reviews
  • 1998
A major challenge for public health officials in all tropical areas of the world is to devleop and implement sustainable prevention and control programs that will reverse the trend of emergent dengue hemorrhagic fever.

The global distribution and burden of dengue

These new risk maps and infection estimates provide novel insights into the global, regional and national public health burden imposed by dengue and will help to guide improvements in disease control strategies using vaccine, drug and vector control methods, and in their economic evaluation.

Serotype-Specific Structural Differences in the Protease-Cofactor Complexes of the Dengue Virus Family

The structure reveals for the first time serotype-specific structural elements in the dengue virus family, with the reported alternate conformation resulting from a unique metal-binding site within the DEN1 sequence.

Dengue: a continuing global threat

A global strategy aimed at increasing the capacity for surveillance and outbreak response, changing behaviours and reducing the disease burden using integrated vector management in conjunction with early and accurate diagnosis has been advocated.

Drug repurposing approaches to fight Dengue virus infection and related diseases.

The most recent drug repurposing approaches to fight DENV infection and their implications in antiviral drug-discovery are described.