A Movie of RNA Polymerase II Transcription


We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition. The movie reveals open questions about the mechanism of transcription and provides a useful teaching tool.

DOI: 10.1016/j.cell.2012.06.006

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@article{Cheung2012AMO, title={A Movie of RNA Polymerase II Transcription}, author={Alan C. M. Cheung and Patrick Cramer}, journal={Cell}, year={2012}, volume={149}, pages={1431-1437} }