A Mouse for All Reasons
@article{Collins2007AMF, title={A Mouse for All Reasons}, author={F. Collins and J. Rossant and W. Wurst}, journal={Cell}, year={2007}, volume={128}, pages={9-13} }
Three major mouse knockout programs are underway worldwide, working together to mutate all protein-encoding genes in the mouse using a combination of gene trapping and gene targeting in mouse embryonic stem (ES) cells. Although the current emphasis is on production of this valuable resource, there are significant efforts to facilitate program coordination, to enhance the availability of this resource, and to plan for future efforts in mouse genetics research.
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391 Citations
Trends in large-scale mouse mutagenesis: from genetics to functional genomics
- Biology, Medicine
- Nature Reviews Genetics
- 2008
- 88
A conditional knockout resource for the genome-wide study of mouse gene function
- Biology, Medicine
- Nature
- 2011
- 1,208
- PDF
The mammalian gene function resource: the international knockout mouse consortium
- Biology, Medicine
- Mammalian Genome
- 2012
- 222
- PDF
Identifying essential genes in mouse development via an ENU-based forward genetic approach.
- Biology, Medicine
- Methods in molecular biology
- 2014
- 4
Mouse mutants and phenotypes: accessing information for the study of mammalian gene function.
- Biology, Medicine
- Methods
- 2011
- 8
- PDF
Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling
- Biology, Medicine
- Nature Reviews Genetics
- 2009
- 98
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