A Mouse for All Reasons

@article{Collins2007AMF,
  title={A Mouse for All Reasons},
  author={F. Collins and J. Rossant and W. Wurst},
  journal={Cell},
  year={2007},
  volume={128},
  pages={9-13}
}
  • F. Collins, J. Rossant, W. Wurst
  • Published 2007
  • Medicine, Biology
  • Cell
  • Three major mouse knockout programs are underway worldwide, working together to mutate all protein-encoding genes in the mouse using a combination of gene trapping and gene targeting in mouse embryonic stem (ES) cells. Although the current emphasis is on production of this valuable resource, there are significant efforts to facilitate program coordination, to enhance the availability of this resource, and to plan for future efforts in mouse genetics research. 
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    References

    SHOWING 1-10 OF 18 REFERENCES
    The Knockout Mouse Project
    • 562
    • PDF
    A public gene trap resource for mouse functional genomics
    • 206
    • PDF
    Genomewide production of multipurpose alleles for the functional analysis of the mouse genome.
    • 171
    • PDF
    A reliable lacZ expression reporter cassette for multipurpose, knockout‐first alleles
    • 180
    • PDF
    High-throughput engineering of the mouse genome coupled with high-resolution expression analysis
    • 373
    • Highly Influential
    • PDF
    Recombineering: a powerful new tool for mouse functional genomics
    • 753
    • PDF
    Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes.
    • 86
    • PDF
    A new logic for DNA engineering using recombination in Escherichia coli
    • 1,089
    Genesis
    • 381