A Mouse Serine/Threonine Kinase Homologous to C. elegans UNC51 Functions in Parallel Fiber Formation of Cerebellar Granule Neurons

@article{Tomoda1999AMS,
  title={A Mouse Serine/Threonine Kinase Homologous to C. elegans UNC51 Functions in Parallel Fiber Formation of Cerebellar Granule Neurons},
  author={Toshifumi Tomoda and Rupal S. Bhatt and Hidehito Kuroyanagi and Takuji Shirasawa and Mary E Hatten},
  journal={Neuron},
  year={1999},
  volume={24},
  pages={833-846}
}
The formation of the cerebellar circuitry depends on the outgrowth of connections between the two principal classes of neurons, granule neurons and Purkinje neurons. To identify genes that function in axon outgrowth, we have isolated a mouse homolog of C. elegans UNC51, which is required for axon formation, and tested its function in cerebellar granule neurons. Murine Unc51.1 encodes a novel serine/threonine kinase and is expressed in granule cells in the cerebellar cortex. Retroviral infection… CONTINUE READING

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