A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury

Abstract

A validated animal model would assist with research on the immunological consequences of the chronic expression of stress keratins KRT6, KRT16, and KRT17, as observed in human pre-malignant hyperproliferative epithelium. Here we examine keratin gene expression profile in skin from mice expressing the E7 oncoprotein of HPV16 (K14E7) demonstrating… (More)
DOI: 10.1016/j.ebiom.2016.06.011

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@inproceedings{Zhussupbekova2016AMM, title={A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury}, author={Samal Zhussupbekova and Rohit Sinha and Paula T Y Kuo and Paul F Lambert and Ian H Frazer and Zewen Kelvin Tuong}, booktitle={EBioMedicine}, year={2016} }