A Mouse Model for Studying Viscerotropic Disease Caused by Yellow Fever Virus Infection

@inproceedings{Meier2009AMM,
  title={A Mouse Model for Studying Viscerotropic Disease Caused by Yellow Fever Virus Infection},
  author={Kathryn C. Meier and Christina L. Gardner and Mikhail V. Khoretonenko and William B Klimstra and Kate D. Ryman},
  booktitle={PLoS pathogens},
  year={2009}
}
Mosquito-borne yellow fever virus (YFV) causes highly lethal, viscerotropic disease in humans and non-human primates. Despite the availability of efficacious live-attenuated vaccine strains, 17D-204 and 17DD, derived by serial passage of pathogenic YFV strain Asibi, YFV continues to pose a significant threat to human health. Neither the disease caused by wild-type YFV, nor the molecular determinants of vaccine attenuation and immunogenicity, have been well characterized, in large part due to… CONTINUE READING

6 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Rapid viremic dissemination and extensive replication in visceral organs , spleen and liver , was associated with severe pathologies in these tissues and dramatically elevated MCP-1 and IL-6 levels , suggestive of a cytokine storm .
Rapid viremic dissemination and extensive replication in visceral organs , spleen and liver , was associated with severe pathologies in these tissues and dramatically elevated MCP-1 and IL-6 levels , suggestive of a cytokine storm .
Rapid viremic dissemination and extensive replication in visceral organs , spleen and liver , was associated with severe pathologies in these tissues and dramatically elevated MCP-1 and IL-6 levels , suggestive of a cytokine storm .
Mosquito - borne yellow fever virus ( YFV ) causes highly lethal , viscerotropic disease in humans and non - human primates .
Rapid viremic dissemination and extensive replication in visceral organs , spleen and liver , was associated with severe pathologies in these tissues and dramatically elevated MCP-1 and IL-6 levels , suggestive of a cytokine storm .
Mosquito - borne yellow fever virus ( YFV ) causes highly lethal , viscerotropic disease in humans and non - human primates .
type I interferon receptorGene product plays role in biological processAntiviral Response
We conclude that the ability of wild - type YFV to evade and/or disable components of the IFN - alpha / beta response may be primate - specific such that infection of mice with a functional IFN - alpha / beta antiviral response is attenuated .
Rapid viremic dissemination and extensive replication in visceral organs , spleen and liver , was associated with severe pathologies in these tissues and dramatically elevated MCP-1 and IL-6 levels , suggestive of a cytokine storm .
All Topics