A Mouse Model for Laser-induced Choroidal Neovascularization.

  title={A Mouse Model for Laser-induced Choroidal Neovascularization.},
  author={Ronil S. Shah and Brian T. Soetikno and Michelle Lajko and Amani A Fawzi},
  journal={Journal of visualized experiments : JoVE},
The mouse laser-induced choroidal neovascularization (CNV) model has been a crucial mainstay model for neovascular age-related macular degeneration (AMD) research. By administering targeted laser injury to the RPE and Bruch's membrane, the procedure induces angiogenesis, modeling the hallmark pathology observed in neovascular AMD. First developed in non-human primates, the laser-induced CNV model has come to be implemented into many other species, the most recent of which being the mouse. Mouse… CONTINUE READING


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