A Mouse Model for Juvenile Doxorubicin-Induced Cardiac Dysfunction

  title={A Mouse Model for Juvenile Doxorubicin-Induced Cardiac Dysfunction},
  author={Wuqiang Zhu and Weinian Shou and Ronald M Payne and Randall L. Caldwell and Loren Field},
  journal={Pediatric Research},
Doxorubicin (DOX) is a potent antitumor agent. DOX can also induce cardiotoxicity, and high cumulative doses are associated with recalcitrant heart failure. Children are particularly sensitive to DOX-induced heart failure. The ability to genetically modify mice makes them an ideal experimental system to study the molecular basis of DOX-induced cardiotoxicity. However, most mouse DOX studies rely on acute drug administration in adult animals, which typically are analyzed within 1 wk. Here, we… CONTINUE READING