A Mouse Model for Human Norovirus

  title={A Mouse Model for Human Norovirus},
  author={Stefan Taube and Abimbola Olayinka Kolawole and Marina Hoehne and John Erby Wilkinson and Scott A Handley and Jeffrey William Perry and Larissa B. Thackray and Ramesh Akkina and Christiane E Wobus},
UNLABELLED Human noroviruses (HuNoVs) cause significant morbidity and mortality worldwide. However, despite substantial efforts, a small-animal model for HuNoV has not been described to date. Since "humanized" mice have been successfully used to study human-tropic pathogens in the past, we challenged BALB/c mice deficient in recombination activation gene (Rag) 1 or 2 and common gamma chain (γc) (Rag-γc) engrafted with human CD34+ hematopoietic stem cells, nonengrafted siblings, and… CONTINUE READING
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