A Morphological Distinction between Neurones of the Male and Female, and the Behaviour of the Nucleolar Satellite during Accelerated Nucleoprotein Synthesis

  title={A Morphological Distinction between Neurones of the Male and Female, and the Behaviour of the Nucleolar Satellite during Accelerated Nucleoprotein Synthesis},
  author={Murray L. Barr and Ewart G. Bertram},
GENETICISTS have long emphasized that ‘maleness’ and ‘femaleness’, so far as chromosome content is concerned, are projected from the fertilized ovum into the morphologically and functionally specialized somatic cells. It appears not to be generally known, however, that the sex of a somatic cell as highly differentiated as a neurone may be detected with no more elaborate equipment than a compound microscope following staining of the tissue by the routine Nissl method. 
Detection of the Sex of Cat Embryos from Nuclear Morphology in the Embryonic Membrane
Evidence available so far suggests that the sex chromatin of females represents heterochromatic portions of the two X chromosomes. Expand
Sex Chromatin (‘Chromoleme’) in the Purkinje Nerve Cells of some Mammals
The studies of Luers1 on the blood cells of Lagomorpha, and of Castro et al.2 on the ameloblasts of Rodentia, showed the possibility of determining the sex in these animals. Expand
Effect of Sexual Maturation and Castration on the Sex Chromatin Pattern in the Male Rat
In leukocytes the hormonal relations of the sex chromatins, especially those of the pseudo-forms are studied, because it cannot be unambiguously explained how it is possible that chromosome pairs have so many, variegated and yet nonspecific morphological equivalents. Expand
Observations on the so-called sex chromatin
  • J. James
  • Biology, Medicine
  • Zeitschrift für Zellforschung und Mikroskopische Anatomie
  • 2004
In oral mucosal smears the disappearance of Barr's corpuscle was shown to go parallel with degenerative changes in the nuclei of the desquamated epithelial cells, in tissue culture preparations to be accompanied by progressive abnormality in the karyotype. Expand
The Sex Chromatin of Interphase Nuclei in the Nine-Banded Armadillo Dasypus novemcinctus
Nervous tissue proved unsuitable for sexing both in young and adult armadillos, in accordance with Benirschke's earlier findings in these animals. Expand
Representation of the X Chromosome in Intermitotic Nuclei in Man
This work describes a persistent connexion between the sex chromosomes and the nucleoli in human fœtal liver based on observations made in ignorance of Reitalu's, of similar structures seen elsewhere. Expand
The observation that the neurons of the ganglia of the periesophageal chain of hermaphrodite and separate-sexed molluscs present different characteristics permits an identification of the somatic sex of mollUScs independently of a knowledge of their genital organs. Expand
Occurrence of Sex Chromatin in the Cells of the Blood and Bone Marrow in Man
This work has confirmed the finding of a morphological sex difference in the mature polymorphonuclear granulocytes of the human subject; these cells show a drumstick-like process which is present in 1–7 per cent of the nuclei in the female, but in less than 1 per cent in the male. Expand
The Possible Significance of Sex-Chromatin for the Determination of Genetic Sex in Ambisexual Teleost Fishes
The simplicity of this sex-chromatin test for sexual dimorphism has become of vital diagnostic use in the evaluation of genetic sex, especially in man and other mammals, but also in other phyla as well. Expand
A Sex Difference in the Chromatin Structure of the Peripheral Blood Lymphocytes
A large number of investigations have been carried out in this field based on the criteria outlined by Barr and his co-workers, finding the presence of sex-specific nuclear appendages in granulocytes of the peripheral blood. Expand


Ribonucleic Acids in Both Nucleus and Cytoplasm, and the Function of the Nucleolus.
  • T. Caspersson, J. Schultz
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1940