A Morphogenesis Checkpoint Monitors the Actin Cytoskeleton in Yeast

@article{McMillan1998AMC,
  title={A Morphogenesis Checkpoint Monitors the Actin Cytoskeleton in Yeast },
  author={John N. McMillan and Rey A.L. Sia and Daniel J. Lew},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={142},
  pages={1487 - 1499}
}
A morphogenesis checkpoint in budding yeast delays cell cycle progression in response to perturbations of cell polarity that prevent bud formation (Lew, D.J., and S.I. Reed. 1995. J. Cell Biol. 129:739- 749). The cell cycle delay depends upon the tyrosine kinase Swe1p, which phosphorylates and inhibits the cyclin-dependent kinase Cdc28p (Sia, R.A.L., H.A. Herald, and D.J. Lew. 1996. Mol. Biol. Cell. 7:1657- 1666). In this report, we have investigated the nature of the defect(s) that trigger… CONTINUE READING

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