A Molecular View of Kinetochore Assembly and Function

  title={A Molecular View of Kinetochore Assembly and Function},
  author={Andrea Musacchio and Arshad Desai},
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to its daughters. Kinetochores also control feedback mechanisms responsible for the correction of incorrect microtubule attachments, and for the coordination of chromosome attachment with cell cycle progression. Finally, kinetochores contribute to their own preservation, across generations, at the specific… CONTINUE READING
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Molecular basis of outer kinetochore assembly on cenp-t. eLife 2016

  • P. J. Huis in ’t Veld, S. Jeganathan, +5 authors A. Musacchio
  • 2016
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