A Molecular Titration System Coordinates Ribosomal Protein Gene Transcription with Ribosomal RNA Synthesis.

@article{Albert2016AMT,
  title={A Molecular Titration System Coordinates Ribosomal Protein Gene Transcription with Ribosomal RNA Synthesis.},
  author={Benjamin Albert and Britta J Knight and Jason R Merwin and Victoria L Martin and Diana Silvia Ottoz and Yvonne Gloor and Maria Jessica Bruzzone and Adam D Rudner and David Shore},
  journal={Molecular cell},
  year={2016},
  volume={64 4},
  pages={
          720-733
        }
}
Cell growth potential is determined by the rate of ribosome biogenesis, a complex process that requires massive and coordinated transcriptional output. In the yeast Saccharomyces cerevisiae, ribosome biogenesis is highly regulated at the transcriptional level. Although evidence for a system that coordinates ribosomal RNA (rRNA) and ribosomal protein gene (RPG) transcription has been described, the molecular mechanisms remain poorly understood. Here we show that an interaction between the RPG… CONTINUE READING
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