A Molecular Rhythm Mediating Circadian Clock Output in Drosophila

  title={A Molecular Rhythm Mediating Circadian Clock Output in Drosophila},
  author={Gerard P. McNeil and Xiaolan Zhang and Ginka Genova and F A Jackson},
Analysis of the Drosophila lark gene indicates that it encodes an RNA-binding protein that functions as a regulatory element of the circadian clock output pathway controlling adult eclosion. We now demonstrate that the lark RNA-binding protein oscillates in abundance during the circadian cycle; importantly, the phasing of the lark rhythm is consistent with gene-dosage studies, which indicate that the protein behaves as a repressor molecule. The lark protein rhythm persists in constant… CONTINUE READING


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