A Molecular Mechanism to Regulate Lysosome Motility for Lysosome Positioning and Tubulation

@inproceedings{Li2016AMM,
  title={A Molecular Mechanism to Regulate Lysosome Motility for Lysosome Positioning and Tubulation},
  author={Xinran Li and Nicholas Rydzewski and Ahmad Hider and Xiaoli Zhang and Junsheng Yang and Wuyang Wang and Qiong Gao and Xiping Cheng and Haoxing Xu},
  booktitle={Nature Cell Biology},
  year={2016}
}
To mediate the degradation of biomacromolecules, lysosomes must traffic towards cargo-carrying vesicles for subsequent membrane fusion or fission. Mutations of the lysosomal Ca2+ channel TRPML1 cause lysosomal storage disease (LSD) characterized by disordered lysosomal membrane trafficking in cells. Here we show that TRPML1 activity is required to promote Ca2+-dependent centripetal movement of lysosomes towards the perinuclear region (where autophagosomes accumulate) following autophagy… CONTINUE READING