A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam

  title={A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam},
  author={Roberta G Machicote and M. A. Castillo and M. E. Pacheco and L. Bruzzone},
  journal={Journal of Analytical Methods in Chemistry},
A flow-through optosensing system for oxazepam recognition with fluorescence detection was performed by means of a molecular imprinted polymer based on its acid hydrolysis product, 2-amino-5-chlorobenzophenone. The synthesis was conducted via a noncovalent imprinting methodology, using methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. Hydrolysis (types and concentration of acids), polymer retention capacity, binding properties, and elution… Expand
Synthesis of Diazepam-Imprinted Polymers with Two Functional Monomers in Chloroform Using a Bulk Polymerization Method
Diazepam is a benzodiazepine that has the potency to be misused because it is effective, easily obtained, and inexpensive. The misuse of diazepam is to replace illegal drugs and be a sedative.Expand
Synthesis and characterization of molecularly imprinted polymers for the selective extraction of oxazepam from complex environmental and biological samples
The development and characterization of molecularly imprinted polymers for the selective solid-phase extraction of oxazepam at trace levels from environmental water and human urine samples and the use of the MIP helped to limit the matrix effects encountered for the quantification of oxzepam in environmental samples and inhuman urine samples after extraction on an Oasis HLB sorbent. Expand
Molecularly Imprinted Polymers-Coated CdTe Quantum Dots for Highly Sensitive and Selective Fluorescent Determination of Ferulic Acid
It could be concluded that the resultant CdTe-QDs@MIPs offered a new way for rapid and sensitive analysis of FA in the complex matrix. Expand


Paracetamol Sensor Based on Molecular Imprinting by Photosensitive Polymers
A voltammetric paracetamol sensor based on molecularly imprinted polymeric (MIP) micelles was prepared by direct electrodeposition. The MIP micelles were prepared via macromolecule self-assembly ofExpand
Highly sensitive molecularly imprinted electrochemical sensor based on the double amplification by an inorganic Prussian blue catalytic polymer and the enzymatic effect of glucose oxidase.
Experimental results show that double amplification, which is based on the catalysis of inorganic PB films and the enzymatic effect of glucose oxidase, can remarkably increase the assay sensitivity of molecularly imprinted polymer sensors. Expand
Molecularly imprinted polymer sensors for detection in the gas, liquid, and vapor phase
Efforts to apply imprinted polymer sensors for detection of airborne materials and vapors will provide accurate low level vapor detection of chemical agents or pesticides with little to no false positives. Expand
Molecular imprinting: a dynamic technique for diverse applications in analytical chemistry
In this review the advantages, applications, and recent developments in molecular imprinting technology are highlighted. Expand
Flow-injection fluorimetric determination of 1,4-benzodiazepines in pharmaceutical formulations after acid hydrolysis.
A simple, rapid and fully automated flow injection method with fluorimetric detection after hydrolysis with H2SO4 in ethanolic or methanolic medium at room temperature has been developed for theExpand
Designing of molecularly imprinted polymer-based potentiometric sensor for the determination of heparin.
The results indicated that a sensitive potentiometric sensor could be fabricated for the determination of heparin and showed high-selectivity monitoring ofHeparin, shorter response time, wider linear range, lower detection limit, and satisfactory long-term stability. Expand
Molecular Imprinting in Cross‐Linked Materials with the Aid of Molecular Templates— A Way towards Artificial Antibodies
Can binding sites be produced in organic or inorganic polymers—similar to those in antibodies—which are able to recognize molecules and which may have catalytic action? In this article we review aExpand
Molecularly imprinted polymers : man-made mimics of antibodies and their applications in analytical chemistry
An historical perspective of the development of molecular imprinting, H.S. Andersson and I.A. Nicholls fundamental aspects on the synthesis and characterization of imprinted network polymers, B.Expand
Molecularly Imprinted Polymers and Optical Sensing Applications
ABSTRACT The development of optical sensing approaches for analytes of biological, industrial, or environmental concern has reached an enormous significance. Different natural systems such as enzymesExpand
Progress in Development of Molecularly Imprinted Polymers as Sorbents for Sample Preparation
Sample preparation has been one of the most often investigated steps in analytical procedures. These investigations are focused on problems such as isolation of analytes from the sample matrix,Expand