A Molecular Epidemiological Study of var Gene Diversity to Characterize the Reservoir of Plasmodium falciparum in Humans in Africa

@inproceedings{Chen2011AME,
  title={A Molecular Epidemiological Study of var Gene Diversity to Characterize the Reservoir of Plasmodium falciparum in Humans in Africa},
  author={Donald S. Chen and Alyssa E Barry and Aleksandra Leliwa-Sytek and T Smith and Ingrid Peterson and Stuart M. Brown and Florence Migot-Nabias and Philippe Deloron and Moses Mosobo Kortok and Kevin Marsh and Johanna Daily and Daouda Ndiaye and Ousmane Fall Sarr and Souleymane Mboup and Karen P. Day},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND The reservoir of Plasmodium infection in humans has traditionally been defined by blood slide positivity. This study was designed to characterize the local reservoir of infection in relation to the diverse var genes that encode the major surface antigen of Plasmodium falciparum blood stages and underlie the parasite's ability to establish chronic infection and transmit from human to mosquito. METHODOLOGY/PRINCIPAL FINDINGS We investigated the molecular epidemiology of the var… CONTINUE READING
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