A Molecular Dynamics Study on RAGE-Aβ 42 Interaction and the Influence of G 82 S RAGE Polymorphism on Aβ Interaction

@inproceedings{Krishnan2015AMD,
  title={A Molecular Dynamics Study on RAGE-Aβ 42 Interaction and the Influence of G 82 S RAGE Polymorphism on Aβ Interaction},
  author={Sreeram Krishnan and Srinidhi Ravi and Sivabaakiyam Ponmalai and P. Suseela Rani},
  year={2015}
}
Interaction of amyloid peptides (Aβ) with receptor for advanced glycation end products (RAGE) elicits an inflammatory response and augments Alzheimer’s disease (AD) pathology. The present study was aimed to analyse the interactions of different forms of Aβ42 peptide with ligand binding domain of normal and G82S RAGE and their possible consequences in AD pathology. The structures of RAGE ectodomain (3CJJ), monomeric forms of Aβ42 – 1IYT (apolar) and 1Z0Q (polar) and fibrillar (2BEG) were… CONTINUE READING