A Molecular Basis for Integrin M 2 Ligand Binding Promiscuity *

@inproceedings{Yakubenko2002AMB,
  title={A Molecular Basis for Integrin M 2 Ligand Binding Promiscuity *},
  author={Valentin P. Yakubenko and Valeryi K. Lishko and Stephen C.-T. Lam and Tatiana P. Ugarova},
  year={2002}
}
The leukocyte integrin M 2 is a highly promiscuous leukocyte receptor capable of binding a multitude of unrelated ligands. To understand the molecular basis for the broad ligand recognition of M 2, the inter-integrin chimera was created. In the chimeric integrin, the D5 loop5 helix segment comprised of residues Lys–Arg from the MI domain of M 2 was inserted into the framework of L 2. The construct was expressed in HEK 293 cells, and the ability of generated cells to adhere to fibrinogen and its… CONTINUE READING
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