A Molecular Approach to the Study of Genic Hetero- Zygosity in Natural Populations. Ii. Amount of Variation and Degree of Heterozygosity in Natural Populations

Abstract

AS pointed out in the first paper of this series (HUBBY and LEWONTIN 1966) , no one knows at the present time the kinds and frequencies of variant alleles present in natural populations of any organism, with the exception of certain special classes of genes. For human populations we know a good deal about certain polymorphisms for blood cell antigens, serum proteins, and metabolic disorders of various kinds but we can hardly regard these, a priori, as typical of the genome as a whole. Clearly we need a method that will randomly sample the genome and detect a major proportion of the individual allelic substitutions that are segregating in a population. In our previous paper,-we discussed a method for accomplishing this end by means of a study of electrophoretic variants at a large number of loci and we showed that the variation picked up by this method behaves in a simple Mendelian fashion so that phenotypes can be equated to homozygous and heterozygous genotypes at single loci.

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@inproceedings{Lewontin2001AMA, title={A Molecular Approach to the Study of Genic Hetero- Zygosity in Natural Populations. Ii. Amount of Variation and Degree of Heterozygosity in Natural Populations}, author={Richard C. Lewontin and HUBBY}, year={2001} }