A Molecular “Zipper” for Microtubules

  title={A Molecular “Zipper” for Microtubules},
  author={Masahide Kikkawa and Zoltan Metlagel},
Cytoskeleton: Tracking the weakest link
  • E. Kritikou
  • Biology
    Nature Reviews Molecular Cell Biology
  • 2007
It is reported that the fission yeast +TIP, Mal3, interacts with microtubules in a very different way from other MAPs — Mal3 binds to and stabilizesmicrotubules through a specific interaction with the microtubule-lattice seam, which is potentially the weakest part of the micro Tubule.
Mechanochemical Modeling of Dynamic Microtubule Growth Involving Sheet-to-Tube Transition
A Tetris-like growth style of microtubules is described: the stochastic tubulin assembly is regulated by energy and harmonized with the seam zipping such that the sheet keeps a practically constant length during growth.
Environmentally responsive histidine-carboxylate zipper formation between proteins and nanoparticles.
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Superior cervical ganglion-10 protein as a molecular effector of c-Jun N-terminal kinase 1: implications for the therapeutic targeting of Jun N-terminal kinase in nerve regeneration
A model reconciling the microtubule regulatory properties of superior cervical ganglion protein 10 with its role as a JNK effector of regeneration is proposed and remaining issues to be resolved are highlighted.
Etude fonctionnelle de la protéine associée aux microtubules XMAP215/ch-TOG
Resume Les proteines XMAP215/ch-TOG appartiennent a une famille de proteines associees aux microtubules (MAPs), bien conservee tout au long de l'evolution, la famille XMAP215/Dis1. Cette famille joue
Powerful Scientific Projective Technique KANEHA-TIR-Ψ uses an “Integrated and Intensified-Ψ Entangled Quantum Computing”
We present scientific basis of Kapil-Neha Total Internal Reflection Quantum Mechanical Projection Wave function Ψ Technique (KANEHA-TIR-Ψ Projective Technique). KANEHATIR-Ψ projective technique uses
Quantum brain-time matrix — The correlation between brain-mind-time with quantum spin and quantum entanglement: Quantum computation of the brain and representation as a matrix
The relation between Brain or Mind and Consciousness is unknown for quite a while. Several Theories and Compositions have been made by Neurologists all over the Globe; still, the relation is still
Microtubule Dynamics in S.cerevisiae
Controlled fabrication of organic nanotubes via self-assembly of non-symmetric bis-acylurea
We present novel non-symmetric bis-acylurea organogelators that self-assemble into hollow tubular nanostructures upon cooling in solutions. The bis-acylureas have aliphatic end groups of different


Visualization of cell microtubules in their native state
This work has shown that cryo‐electron microscopy of vitrified specimens yields a detailed understanding of the tubulin and microtubule structures of samples reassembled in vitro from purified components, but knowledge of microtubules structure in vivo remains limited by the chemical treatments commonly used to observe cellular architecture using electron microscopy.
Microtubule Plus End: A Hub of Cellular Activities
Recent studies suggest that the members of one particular +TIP family, EB1 and its homologues, are present in all eucaryotic kingdoms, interact directly with the majority of other known plus‐end‐associated proteins and may be responsible for their specific accumulation at the MT tips.
The Molecular Architecture of Axonemes Revealed by Cryoelectron Tomography
The three-dimensional structure of rapidly frozen axonemes from Chlamydomonas and sea urchin sperm is described using cryoelectron tomography and image processing to focus on the motor enzyme dynein, and images suggest a model for the way Dynein generates force to slide microtubules.
Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography
A three-dimensional density map of intact microtubule doublets is obtained using cryo-electron tomography and image averaging, which offers insight on how tubulin protofilaments and accessory proteins attach together to form the doublets and provides a structural basis for understanding doublet function in axonemes.
On the surface lattice of microtubules: helix starts, protofilament number, seam, and handedness
The tubulin monomers of brain microtubules reassembled in vitro are arranged on a 3-start helix, irrespective of whether the number of protofilaments is 13 or 14. The dimer packing is that of the
Direct visualization of the microtubule lattice seam both in vitro and in vivo
Overall the data indicates that microtubules have a predominantly B lattice, but that A lattice bonds between tubulin subunits are found at the seam, which has important implications for the interaction of microtubule with MAPs and with motor proteins, and for example, suggest that kinesin motors may follow a single protofilament track.
EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules.
The highly conserved effect of EB1 on microtubule dynamics suggests it belongs to a core set of regulatory factors conserved in higher organisms, and the complex pattern ofEB1 targeting to microtubules could be exploited by the cell for coordinating microtubULE behaviors.
Quantitative analysis of changes in spatial distribution and plus-end geometry of microtubules involved in plant-cell cytokinesis
The cell-plate assembly matrix is shown to stabilize microtubule plus ends, as evidenced by the fact that of these microtubules that do not terminate in such a matrix, 40-80% are horn-shaped (shrinking), whereas of those that end in suchA matrix, 50-70% are blunt (metastable).
APC binds to the novel protein EB1.
Conservation of the EB1 gene suggests an essential function for EB1 that might provide clues to the mechanism through which APC suppresses colonic neoplasia.