A Modular Gain-of-Function Approach to Generate Cortical Interneuron Subtypes from ES Cells

@article{Au2013AMG,
  title={A Modular Gain-of-Function Approach to Generate Cortical Interneuron Subtypes from ES Cells},
  author={Edmund Au and Tanzeel Ahmed and Theofanis Karayannis and Shiona Biswas and Lin Gan and Gordon Fishell},
  journal={Neuron},
  year={2013},
  volume={80},
  pages={1145-1158}
}
Whereas past work indicates that cortical interneurons (cINs) can be generically produced from stem cells, generating large numbers of specific subtypes of this population has remained elusive. This reflects an information gap in our understanding of the transcriptional programs required for different interneuron subtypes. Here, we have utilized the directed differentiation of stem cells into specific subpopulations of cortical interneurons as a means to identify some of these missing factors… CONTINUE READING
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