A Modular Flow Design for the meta‐Selective C−H Arylation of Anilines

@inproceedings{Gemoets2017AMF,
  title={A Modular Flow Design for the meta‐Selective C−H Arylation of Anilines},
  author={Hannes P L Gemoets and Gabriele Laudadio and Kirsten Verstraete and Volker Hessel and Timothy No{\"e}l},
  booktitle={Angewandte Chemie},
  year={2017}
}
Described herein is an effective and practical modular flow design for the meta-selective C-H arylation of anilines. The design consists of four continuous-flow modules (i.e., diaryliodonium salt synthesis, meta-selective C-H arylation, inline copper extraction, and aniline deprotection) which can be operated either individually or consecutively to provide direct access to meta-arylated anilines. With a total residence time of 1 hour, the desired product could be obtained in high yield and… CONTINUE READING

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