A Modular Design for the Clathrin- and Actin-Mediated Endocytosis Machinery

  title={A Modular Design for the Clathrin- and Actin-Mediated Endocytosis Machinery},
  author={Marko Kaksonen and Christopher P Toret and David G Drubin},
Endocytosis depends on an extensive network of interacting proteins that execute a series of distinct subprocesses. Previously, we used live-cell imaging of six budding-yeast proteins to define a pathway for association of receptors, adaptors, and actin during endocytic internalization. Here, we analyzed the effects of 61 deletion mutants on the dynamics of this pathway, revealing functions for 15 proteins, and we analyzed the dynamics of 8 of these proteins. Our studies provide evidence for… CONTINUE READING
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