A Model of DENV-3 Infection That Recapitulates Severe Disease and Highlights the Importance of IFN-γ in Host Resistance to Infection

Abstract

There are few animal models of dengue infection, especially in immunocompetent mice. Here, we describe alterations found in adult immunocompetent mice inoculated with an adapted Dengue virus (DENV-3) strain. Infection of mice with the adapted DENV-3 caused inoculum-dependent lethality that was preceded by several hematological and biochemical changes and… (More)
DOI: 10.1371/journal.pntd.0001663

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@inproceedings{Costa2012AMO, title={A Model of DENV-3 Infection That Recapitulates Severe Disease and Highlights the Importance of IFN-γ in Host Resistance to Infection}, author={Vivian Vasconcelos Costa and Caio Tavares Fagundes and Deborah F. Valad{\~a}o and Daniel Cisalpino and Ana Carolina Fialho Dias and K{\'a}tia Daniela da Silveira and Lucas Miranda Kangussu and Thiago Vin{\'i}cius {\'A}vila and Maria Rosa Q. Bonfim and Daniela Bonaventura and Tarc{\'i}lia A Silva and Lirl{\^a}ndia P Sousa and Milene Alvarenga Rachid and Leda Qu{\'e}rcia Vieira and Gustavo Batista Menezes and Ana Maria de Paula and Alena V. Atrasheuskaya and George M Ignatyev and Mauro M Teixeira and Danielle da Gl{\'o}ria de Souza}, booktitle={PLoS neglected tropical diseases}, year={2012} }