A Model of Autophagy Size Selectivity by Receptor Clustering on Peroxisomes

@article{Brown2016AMO,
  title={A Model of Autophagy Size Selectivity by Receptor Clustering on Peroxisomes},
  author={Aidan I. Brown and Andrew David Rutenberg},
  journal={Frontiers in Physics},
  year={2016},
  volume={5},
  pages={14}
}
Selective autophagy must not only select the correct type of organelle, but also must discriminate between individual organelles of the same kind so that some but not all of the organelles are removed. We propose that physical clustering of autophagy receptor proteins on the organelle surface can provide an appropriate all-or-none signal for organelle degradation. We explore this proposal using a computational model restricted to peroxisomes and the relatively well characterized pexophagy… 

Figures from this paper

References

SHOWING 1-10 OF 92 REFERENCES

NBR1 acts as an autophagy receptor for peroxisomes

Results suggest that NBR1 is the specific autophagy receptor for pexophagy, and that substrate selectivity is partly achieved by N BR1 itself by coincident binding of the J and UBA domains to peroxisomes.

Peroxisome size provides insights into the function of autophagy-related proteins.

A yeast model system is developed to study the effect of cargo size on the requirement of autophagy-related (Atg) proteins and found that peroxisome size determines the requirements of Atg11 and Atg26, suggesting it is a component of the core autophagic machinery.

Excess Peroxisomes Are Degraded by Autophagic Machinery in Mammals*

It is shown that Atg7, an essential gene for autophagy, plays a pivotal role in the degradation of excess peroxisomes in mammals and is the first direct evidence for the contribution of autophagic machinery inperoxisomal degradation in mammals.

The LIR motif – crucial for selective autophagy

Comment on new insights on the interactions of LIR-containing proteins with members of the ATG8 protein family on the interaction of autophagy receptors to LC3-interacting region proteins anchored in the phagophore membrane.

Peroxisome Dynamics in Cultured Mammalian Cells

It is shown that peroxisomes display an age‐related heterogeneity with respect to their capacity to incorporate newly synthesized proteins, and it is demonstrated that these organelles do not exchange their protein content.

Emerging role of selective autophagy in human diseases

The principle components of selective autophagy processes and their emerging importance in human disease are outlined, with an emphasis on pulmonary diseases.

Damaged peroxisomes are subject to rapid autophagic degradation in the yeast Hansenula polymorpha

It is shown that peroxisomes that are damaged by the abrupt removal of the membrane protein Pex3 are massively and rapidly degraded even when the cells are placed at peroxISome-inducing conditions and hence need the organelles for growth.

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

It is proposed that phosphorylation of autophagy receptors might be a general mechanism for regulation of cargo-selectiveautophagy, resulting in increased intracellular bacterial proliferation.
...