A Model of Autophagy Size Selectivity by Receptor Clustering on Peroxisomes

  title={A Model of Autophagy Size Selectivity by Receptor Clustering on Peroxisomes},
  author={Aidan I. Brown and Andrew David Rutenberg},
  journal={Frontiers in Physics},
Selective autophagy must not only select the correct type of organelle, but also must discriminate between individual organelles of the same kind so that some but not all of the organelles are removed. We propose that physical clustering of autophagy receptor proteins on the organelle surface can provide an appropriate all-or-none signal for organelle degradation. We explore this proposal using a computational model restricted to peroxisomes and the relatively well characterized pexophagy… 

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