A Model of [ ]-Cell Mass, Insulin, Glucose, and Receptor Dynamics with Applications to Diabetes

  title={A Model of [ ]-Cell Mass, Insulin, Glucose, and Receptor Dynamics with Applications to Diabetes},
  author={Ryan D. Hernandez and Danielle J. Lyles and Daniel D. Ben-Dayan Rubin and Stephen A. Wirkus},
Approximately 15.7 million people in the United States suffer from diabetes mellitus, of which about 90% are classified as type II [13]. Most cases of type II diabetes mellitus are characterized by high blood glucose levels resulting from chronic insulin resistance, [30], which then leads to significant β-cell mass reduction from “β-cell exhaustion” and/or “glucose toxicity” [1]. Existing mathematical models of β-cell mass, insulin, and glucose kinetics contribute to the study of the disease by… CONTINUE READING


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