A Model of [ ]-Cell Mass, Insulin, Glucose, and Receptor Dynamics with Applications to Diabetes

@inproceedings{Hernandez2001AMO,
  title={A Model of [ ]-Cell Mass, Insulin, Glucose, and Receptor Dynamics with Applications to Diabetes},
  author={Ryan D. Hernandez and Danielle J. Lyles and Daniel D. Ben-Dayan Rubin and Stephen A. Wirkus},
  year={2001}
}
Approximately 15.7 million people in the United States suffer from diabetes mellitus, of which about 90% are classified as type II [13]. Most cases of type II diabetes mellitus are characterized by high blood glucose levels resulting from chronic insulin resistance, [30], which then leads to significant β-cell mass reduction from “β-cell exhaustion” and/or “glucose toxicity” [1]. Existing mathematical models of β-cell mass, insulin, and glucose kinetics contribute to the study of the disease by… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

A model of β-cell mass, insulin, and glucose kinetics: pathways to diabetes

  • B. Topp, K. Promislow, G. de Vries, R. Miura, D. Finegood
  • J. Theor. Biol
  • 2000
Highly Influential
10 Excerpts

Chapter 14 in Joslin’s Diabetes Mellitus

  • G. Weir, J. Leahy
  • Thirteenth edition. Joslin Diabetes Center
  • 1994
Highly Influential
7 Excerpts

Chapter 334: Diabetes Mellitus - Pathogenesis of IDDM

  • D W.Foster
  • February 20,
  • 2001
Highly Influential
3 Excerpts

Islets of Langerhans: Morphology and its Implications. Chapter 2 in Joslin’s Diabetes Mellitus

  • S. Bonner-Weir, F. Smith
  • Thirteenth edition. Joslin Diabetes Center…
  • 1994
Highly Influential
4 Excerpts

Quantitative Study of insulin secretion and clearance in normal and obese subjects

  • K S.Polonsky, B D.Given, +7 authors E. Van Cauter
  • J. Clin. Invest
  • 1988
Highly Influential
4 Excerpts

Insulin Resistance

  • T R.Dorsch
  • January 25,
  • 2000
2 Excerpts

Similar Papers

Loading similar papers…